Biochem Metabolism Bioenergetics>Glycolysis Gluconeogenesis Practice Test

AMP activates FBPase-1 and inhibits PFK-1, signaling low-energy state to favor gluconeogenesis.

Fructose 2,6-bisphosphate activates PFK-1 and inhibits FBPase-1, favoring glycolysis when energy and insulin are high.

Citrate stimulates PFK-1 and suppresses FBPase-1, promoting glycolysis during high TCA flux.

Fructose 2,6-bisphosphate inhibits PFK-1 and activates FBPase-1 to drive gluconeogenesis in the fed state.