Mitosis and Meiosis - MCAT Biological and Biochemical Foundations of Living Systems

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Question

A mouse has a mutation in which its sister chromatids are unable to separate during cell division. What phase of mitosis should researchers target, in order to alleviate the condition using drug therapy?

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Answer

During anaphase, sister chromatids are separated and pulled to polar ends of the cell. Drug therapy would best be able to target the mutation during this phase of mitosis.

Chromosomes condense and exit the nucleus during prophase. Alignment along the equatorial plate occurs during metaphase. Separation occurs during anaphase, and the nuclei begin to re-form during telophase in preparation for cytokinesis.

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