Understanding the Cell Membrane - AP Biology

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Question

Where would aspartic acid, an amino acid with a negatively charged side chain, most likely be found in a transmembrane protein?

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Answer

Any amino acid with a charged side chain will be polar. Membranes have hydrophobic tails on the interior, and hydrophilic heads facing the outside and inside of the cell. Since polar molecules are charged, they will interact with the hydrophilic parts of the environment, and therefore they will not be found within the membrane interior.

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